Benzo (a) Pyrene ProductionDuringControlled Combustion
نویسندگان
چکیده
منابع مشابه
Benzo[a]pyrene prioritization
This is a compilation of abstracts of articles identified during the preliminary toxicological evaluation of evidence on the developmental and reproductive toxicity of benzo[a]pyrene (BaP, CAS# 50-32-8). BaP is a polycyclic aromatic hydrocarbon and a component of air pollution. Polycyclic aromatic hydrocarbons are formed as a result of incomplete combustion of organic materials and are ubiquito...
متن کاملInhibition of Benzo(a)pyrene and Benzo(a)pyrene 7,8-Dihydrodiol Metabolism by Benzo(a)pyrene Quiñones1
Benzo(a)pyrene 1,6-, 3,6-, and 6,1 2-quinones were found to be noncompetitive inhibitors of mixed-function oxidation of benzo(a)pyrene (BP) and frans-7,8-dihydro-7,8-dihydroxybenzo(a)pyrene (BP 7,8-dihydrodiol). BP 6,1 2-quinone was the most potent inhibitor of both BP and BP-7,8-dihydrodiol oxi dation followed by BP 1,6-quinone and BP 3,6-quinone. The K, for inhibition of BP mixed-function oxi...
متن کاملInhibition of benzo(a)pyrene and benzo(a)pyrene 7,8-dihydrodiol metabolism by benzo(a)pyrene quinones.
Benzo(a)pyrene 1,6-, 3,6-, and 6,1 2-quinones were found to be noncompetitive inhibitors of mixed-function oxidation of benzo(a)pyrene (BP) and frans-7,8-dihydro-7,8-dihydroxybenzo(a)pyrene (BP 7,8-dihydrodiol). BP 6,1 2-quinone was the most potent inhibitor of both BP and BP-7,8-dihydrodiol oxi dation followed by BP 1,6-quinone and BP 3,6-quinone. The K, for inhibition of BP mixed-function oxi...
متن کاملDifferential metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 variants.
Cytochrome P450 1A1 (CYP1A1) plays a key role in the metabolism of carcinogens, such as benzo[a]pyrene (B[a]P) and metabolites to ultimate carcinogens. Three human allelic variants, namely wild-type (CYP1A1.1), CYP1A1.2 (I462V) and CYP1A1.4 (T461N), were coexpressed by coinfection of baculovirus-infected insect cells with human NADPH-P450 reductase. These recombinant enzymes (in microsomal memb...
متن کاملMutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides.
Four benzo-ring epoxides of the environmental carcinogen benzo(a)pyrene (BP) were tested for mutagenic and cytotoxic activity in 3 strains of Salmonella typhimurium (TA1538, TA98, and TA100) and in Chinese hamster V79 cells. Although very unstable in aqueous solution, 7beta,8alpha-dihydroxy-0beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (diol epoxide 1), with the 7-hydroxyl group on the s...
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ژورنال
عنوان ژورنال: Journal of the Air Pollution Control Association
سال: 1963
ISSN: 0002-2470
DOI: 10.1080/00022470.1963.10468219